Close this search box.
Close this search box.

How LDN Works with Your Immune System Not Against it


You may not spend too much time thinking about your immune system. When you are healthy, it’s easy to take it for granted. It is only when it becomes compromised, or your risk of a virus increases, that you start to pay attention. 

Your immune system protects you from external health risks like toxins, fungi, bacteria, and viruses. There are two main parts, the innate system that you are born with and the adaptive system, which is developed with exposure. Your immune system is robust and fights off disease. 

Low dose naltrexone (LDN) is theorized to help modulate the immune system. It does so by working with your immune system, not against it and as a result, it empowers your body to create its own therapeutic effects.  

Naltrexone has been prescribed for over 40 years with an incredible safety record. It is FDA-approved to treat obesity and opiate dependencies. When the drug is delivered at a lower dose, below 10mg/day, it is considered “Low Dose Naltrexone,” which possesses a unique set of health and longevity benefits. In addition, LDN has been used to treat auto-immune disease and viral infections since 1985 and exhibits novel effects for various conditions.  It also is theorized to impact aging pathways and potentially improve longevity. 

Many of LDNs potential longevity benefits are achieved because of its impact on the immune system. This is through Met-enkephalin. Met-enkephalins are opioids found primarily in the adrenal gland and the Central Nervous System and bind to opiate receptors. This regulates memory and emotional conditions, releases controlled levels of pain and regulates the immune system.. 

When you take LDN, it works with your immune system by increasing Met-enkephalin levels. By intermittently blocking opioid receptors, it increases endorphin release, modulating the immune system and reducing inflammation. In addition, research has found that Met-enkephalin can stimulate an immune response, which has a positive effect on immune cells. 

The journal of Human Vaccines & Immunotherapeutics published a study in 2014 that examined 50 cancer patients. When these patients were given Met-enkephaline boosters, their immune systems improved. The researchers concluded that Met-enkephaline “could work as a strong immune booster with great potential in restoring the damaged human immune system, and we could consider MENK as a drug to treat cancer patients whose immune systems are damaged by chemo or radiotherapy. Furthermore, we could consider MENK as a chemotherapy additive, which would sustain an immune system of cancer patients during the process of chemotherapy to get maximized efficacy with minimized side effects”. 

Another 2014 study published in Mini Reviews in Medicinal Chemistry found that Met-enkephalin played a role in increasing the number of T cells. T cells help with immunity to foreign substances and improve host resistance to viral infections or tumor growth. 

In sum, LDN increases Met-enkephalin, which increases T-cells and NK cells, IL-2, and TH-2, which could decrease AIDS, opportunistic diseases, and cancers such as colon, prostate, lung pancreatic, and squamous-cell.  

The benefits continue as LDN also reduces pro-inflammatory cytokines. As you age, your immune system becomes weaker and chronic inflammation can set it. Studies have found that by taking LDN, you can reduce inflammation. For example, an 8-week, single-blind pilot study gave women 4.5 mg of LDN each night. The serum levels of pro-inflammatory cytokines were measured and had been significantly reduced. Therefore, by reducing inflammation, LDN strengthens the immune system. 

Additional clinical evidence, as well as anecdotal reports, support the drug’s effectiveness for treating various conditions and auto-immune diseases. For example, LDN is known to aid in chronic inflammation and auto-immune conditions such as Rheumatoid arthritis, Multiple Sclerosis, Fibromyalgia, Crohn’s and Ulcerative Colitis, Thyroid Dysregulation, and anxiety. In addition, the 2020 BMJ Case Reports cite patient reports of improved energy levels, reduced joint pain, and improved cognitive impairment. 

You can learn more about LDN and schedule a consultation with a knowledgeable medical professional via an online wellness platform like, that will take you through the process from beginning to end.

Generally, a 4.5 mg dose is prescribed; however, this can be altered. When taking LDN for the first time, you will be started at a lower dose of 1.5mg/day. Over a 20-day period, you will slowly work your way up to the prescribed dose. If you find you have a hard time tolerating it, you can modify it. This involves taking one capsule at bedtime for ten days and then increasing to 2 capsules for an additional ten days.  

LDN should be taken every day at bedtime, between 9 pm and 2 am. When you first begin treatment, you will start to see an improvement like a reduction in symptoms of rampant oxidative stress and inflammation such as joint pain and back pain. Although it varies from person to person, it can also help with brain fog, fatigue, headache, constipation, sleep, seasonal allergies, and skin issues. 

Your health and wellness depend on your immune system. A strong immune system will ward off viruses, infections, and auto-immune disease.

Apart from this, you can also read EntertainmentTech, and Health-related articles here: Rainbow KissMovieRulzSex Education season 3NFL Live StreamYoutbeBailey Sarian Net WorthBollyshareAfdahSamsung Galaxy F22 Review1616 Angel Number444 Angel NumberMoviezwapY8JalshamoviezWebsite traffic checkerProject Free TVKickassanime777 Angel NumberSeptember 8 ZodiacKissasian666 Angel Number333 Angel NumberHoliday SeasonSamsung Galaxy Z Flip 3 reviewPUBG Launch Date in IndiaSears Credit CardGoDaddy EmailFree Fire Redeem CodeMangagoJio RockersNew iPhone 13Vivo Y53s ReviewEye ShapesM4uHDFever DreamMoon wateriPhone HeadphonesSpanish MoviesHip dips,  M4ufreeNBAstreams XYZCCleaner Browser reviewAvocado CaloriesBear Grylls net worthRihanna net worth 2021Highest Paid CEOThe 100 season 8Sundar Pichai net worthGrimes net worthF95Zonehow to change Twitch nameSherlock Season 5Homeland Season 9.


Subscribe to Our Newsletter

Related Articles

Top Trending

Cregan Stark
Meet Cregan Stark: Key Player in 'House of the Dragon' Season 2
iOS 18 Rumors
iOS 18 Rumors: Unveiling iPhone's AI Advances & Features
rubi rose leaks
Rubi Rose Leaks: The Impact of the Alleged Sex Tape Incident in 2024
david bromstad twin brother
David Bromstad Twin Brother Rumors: Inside Story and Updates
Adobe AI Text-to-Video Tool
Adobe Unveils AI Text-to-Video Tool: A Game Changer Over Sora!


Korean Beauty Secrets
10 Korean Beauty Secrets for Youthful Energy: Stay Young & Vibrant
Ancient Philosophers Guide to Happiness
Unlocking Happiness: Timeless Lessons from Ancient Philosophers
eid decor diy
Eid Decor DIY: 15 Creative Ideas to Spruce Up Your Home for the Festivities
50 Worries to Leave Behind When You Hit 50
Top 50 Worries to Leave Behind When You Hit 50 - A Guide
millennial fashion trends
Top 15 Millennial Fashion Trends Coming Back in 2024


Cregan Stark
Meet Cregan Stark: Key Player in 'House of the Dragon' Season 2
rubi rose leaks
Rubi Rose Leaks: The Impact of the Alleged Sex Tape Incident in 2024
david bromstad twin brother
David Bromstad Twin Brother Rumors: Inside Story and Updates
Dark Matter
Explore Apple's New Sci-Fi Hit: 'Dark Matter' Unveiled!
kahoot characters
200 Amazing Kahoot Characters Names for Boys and Girls in 2024


Prime Gaming
Is 2024 the Year Prime Gaming Takes Off?
Online Games for Stress Relief
Finding Calm in the Click: A Comparative Look at Online Games for Stress Relief
Apple Introduces Retro Game Emulators App Store
App Store Welcomes Retro Game Emulators: Apple's New Gaming Era
Nintendo Switch 2
Sneak Peek: What to Expect from the Nintendo Switch 2
tortoise pokemon
Discover the Top 15 Tortoise Pokemon in the Pokemon Universe


Tesla and Reliance Join Forces for Manufacturing Venture
Tesla and Reliance Join Forces for New India Manufacturing Venture
Entrepreneurs are receiving money
Peace of Mind: Stability Through Payday Loan Assistance
Tips For Successful Business Plan
Mastering Business Plans: Essential Tips for Success
Better Workplace Culture
Creating a Better Workplace Culture
Sam Altman of OpenAI Joins Billionaire Ranks
Sam Altman of OpenAI Joins Billionaire Ranks, Forbes Announces


iOS 18 Rumors
iOS 18 Rumors: Unveiling iPhone's AI Advances & Features
Adobe AI Text-to-Video Tool
Adobe Unveils AI Text-to-Video Tool: A Game Changer Over Sora!
how ai chatbots are revolutionizing online search
Will AI Chatbots Be the Future of Web Searching?
bill gates ai learning math challenge
Bill Gates: AI Enhances Learning, But Math Remains a Challenge
GPT-4 Turbo
OpenAI Unveils Enhanced GPT-4 Turbo: Key Features & Insights


5 Reasons You Should Go for Facelift Surgery
5 Reasons You Should Go for Facelift Surgery
E-Cigarettes Raise Heart Disease
E-Cigarettes Raise Heart Disease Risk by 20%, Says New Study
Natural Remedies for Common Health Issues
The 15 Best Natural Remedies for Common Health Issues
Respite Care
What To Expect During A Respite Care Stay?
How Does Rehab Work
How Does Rehab Work?