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How LDN Works with Your Immune System Not Against it

LDN

You may not spend too much time thinking about your immune system. When you are healthy, it’s easy to take it for granted. It is only when it becomes compromised, or your risk of a virus increases, that you start to pay attention. 

Your immune system protects you from external health risks like toxins, fungi, bacteria, and viruses. There are two main parts, the innate system that you are born with and the adaptive system, which is developed with exposure. Your immune system is robust and fights off disease. 

Low dose naltrexone (LDN) is theorized to help modulate the immune system. It does so by working with your immune system, not against it and as a result, it empowers your body to create its own therapeutic effects.  

Naltrexone has been prescribed for over 40 years with an incredible safety record. It is FDA-approved to treat obesity and opiate dependencies. When the drug is delivered at a lower dose, below 10mg/day, it is considered “Low Dose Naltrexone,” which possesses a unique set of health and longevity benefits. In addition, LDN has been used to treat auto-immune disease and viral infections since 1985 and exhibits novel effects for various conditions.  It also is theorized to impact aging pathways and potentially improve longevity. 

Many of LDNs potential longevity benefits are achieved because of its impact on the immune system. This is through Met-enkephalin. Met-enkephalins are opioids found primarily in the adrenal gland and the Central Nervous System and bind to opiate receptors. This regulates memory and emotional conditions, releases controlled levels of pain and regulates the immune system.. 

When you take LDN, it works with your immune system by increasing Met-enkephalin levels. By intermittently blocking opioid receptors, it increases endorphin release, modulating the immune system and reducing inflammation. In addition, research has found that Met-enkephalin can stimulate an immune response, which has a positive effect on immune cells. 

The journal of Human Vaccines & Immunotherapeutics published a study in 2014 that examined 50 cancer patients. When these patients were given Met-enkephaline boosters, their immune systems improved. The researchers concluded that Met-enkephaline “could work as a strong immune booster with great potential in restoring the damaged human immune system, and we could consider MENK as a drug to treat cancer patients whose immune systems are damaged by chemo or radiotherapy. Furthermore, we could consider MENK as a chemotherapy additive, which would sustain an immune system of cancer patients during the process of chemotherapy to get maximized efficacy with minimized side effects”. 

Another 2014 study published in Mini Reviews in Medicinal Chemistry found that Met-enkephalin played a role in increasing the number of T cells. T cells help with immunity to foreign substances and improve host resistance to viral infections or tumor growth. 

In sum, LDN increases Met-enkephalin, which increases T-cells and NK cells, IL-2, and TH-2, which could decrease AIDS, opportunistic diseases, and cancers such as colon, prostate, lung pancreatic, and squamous-cell.  

The benefits continue as LDN also reduces pro-inflammatory cytokines. As you age, your immune system becomes weaker and chronic inflammation can set it. Studies have found that by taking LDN, you can reduce inflammation. For example, an 8-week, single-blind pilot study gave women 4.5 mg of LDN each night. The serum levels of pro-inflammatory cytokines were measured and had been significantly reduced. Therefore, by reducing inflammation, LDN strengthens the immune system. 

Additional clinical evidence, as well as anecdotal reports, support the drug’s effectiveness for treating various conditions and auto-immune diseases. For example, LDN is known to aid in chronic inflammation and auto-immune conditions such as Rheumatoid arthritis, Multiple Sclerosis, Fibromyalgia, Crohn’s and Ulcerative Colitis, Thyroid Dysregulation, and anxiety. In addition, the 2020 BMJ Case Reports cite patient reports of improved energy levels, reduced joint pain, and improved cognitive impairment. 

You can learn more about LDN and schedule a consultation with a knowledgeable medical professional via an online wellness platform like AgelessRx.com, that will take you through the process from beginning to end.

Generally, a 4.5 mg dose is prescribed; however, this can be altered. When taking LDN for the first time, you will be started at a lower dose of 1.5mg/day. Over a 20-day period, you will slowly work your way up to the prescribed dose. If you find you have a hard time tolerating it, you can modify it. This involves taking one capsule at bedtime for ten days and then increasing to 2 capsules for an additional ten days.  

LDN should be taken every day at bedtime, between 9 pm and 2 am. When you first begin treatment, you will start to see an improvement like a reduction in symptoms of rampant oxidative stress and inflammation such as joint pain and back pain. Although it varies from person to person, it can also help with brain fog, fatigue, headache, constipation, sleep, seasonal allergies, and skin issues. 

Your health and wellness depend on your immune system. A strong immune system will ward off viruses, infections, and auto-immune disease.

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